Antigen-specific T-cell Factor in Cell Cooperation: Physical Properties and Mapping in the Left-hand (k) Half of H-2
نویسندگان
چکیده
Mouse thymus cells, educated to poly(tyrosyl,glutamyl)-polyDLalanyl--polylysyl [(T,G)-A--L], release an antigen-specific factor on brief culture in vitro. The factor cooperates with bone marrow cells in the antibody response to (T,G)-A--L in irradiated recipients. Its mol wt determined from Sephadex G100 chromatography is in the region of 50,000. The factor is removed by specific antigen-coated columns, but not by anti-immunoglobulin (anti-Fab, anti-micro, anti-Fv) adsorbents. The factor is removed by alloantisera directed against the H-2 haplotype of the strain in which it is produced. Moreover, only antisera with specificity for the K side of H-2 were successful in removing the factor activity.
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 140 شماره
صفحات -
تاریخ انتشار 1974